Researchers David Alland and Soumitesh Chakravorty Receive Award from R&D Council of New Jersey for “Detection of Drug Resistant Mycobacterium Tuberculosis”



NEW BRUNSWICK, NJ — A milestone patent for a rapid, automated test for detecting Mycobacterium tuberculosis (TB) and Rifampicin-resistant M. tuberculosis invented by two Rutgers University researchers received the 2019 Edison Patent Award from the Research & Development Council of New Jersey. The annual award commemorates the state’s most prolific inventor, Thomas Alva Edison, and celebrates New Jersey’s exceptional inventors.


The invention receiving the Edison Patent Award in the biotechnology category, “Detection of Drug Resistant Mycobacterium Tuberculosis” (U.S. Patent 9,708,671 B2) consists of a technology that shortens the time it takes to diagnose tuberculosis from around seven weeks to less than two hours. Rutgers inventor David Alland, chief of infectious disease at Rutgers New Jersey Medical School (NJMS) and director of the Center for Emerging Pathogens and Rutgers Regional Biocontainment Laboratory, and Soumitesh Chakravorty, adjunct assistant professor at NJMS and director of R&D at Cepheid Inc., have brought new hope for people at risk of TB or with drug-resistant TB.


“I’m gratified, pleased and honored with this award but also humbled to know that this is just a very small part of a very large mission. Tuberculosis has become more drug resistant. There was a clear need for better diagnostic,” says Alland. “Tuberculosis tests were not sensitive enough to detect TB in patients who had a small amount of TB in their lungs and particularly in patents who are HIV positive. We knew that this test was missing people who had tuberculosis and had to be improved on.”


Alland and Chakravorty developed the tuberculosis detection test: the first near-patient, on-demand diagnostic test for a highly contagious and drug resistant form of M. tuberculosis which has been declared as a global emergency. The assay isolates and then uses a polymerase chain reaction (PCR) to amplify M. tuberculosis directly from sputum specimens enabling detection of M. tuberculosis and multi-drug-resistant tuberculosis in less than two hours in a single hands-free step. Rutgers’ technology has been licensed by Cepheid, a molecular diagnostics company, and is now used on a global scale in Xpert® MTB/RIF Ultra (CE in vitro diagnostic medical device not available in the United States).


“It is extremely gratifying and humbling to have my name associated with Edison whose patents keep lighting up our lives,” says Chakravorty. “This test is faster, more sensitive, more accurate and more definitive. We are getting the same results that were taking over six weeks using conventional diagnostics, in 70 minutes. The patent really revolutionized the diagnostics of drug resistant tuberculosis.”


Xpert® MTB/RIF Ultra has been endorsed and recommended by the World Health Organization (WHO) since 2017. According to the latest WHO Global Tuberculosis Report published in 2019, 10 million people developed TB last year and 1.5 million lost their lives to the disease.


Rutgers University is among over 60 winners of the 2019 Edison Patent Awards, which was in its 40th edition. Co-inventors Alland and Chakravorty accepted the award on November 14th at a ceremony held at Liberty Science Center in Jersey City.


The awards for innovative patent work spanned 15 R&D categories, including: information technology, environmental, enabling technology, medical technology, medical device, energy, industrial process, emerging therapy, pharmaceutical, agriculture, telecommunications, biotechnology, smart grid., medical imaging and telecommunication systems.


Recipients of the 2019 Edison Patent Awards included: Avaya Inc., BASF Corporation, Bristol-Myers Squibb, Celgene Corporation, Ethicon, Inc., a Johnson & Johnson Company, ExxonMobil Research & Engineering Company, Honeywell International, Insmed Incorporated, Merck & Co. Inc., New Jersey Institute of Technology, Nokia Bell Labs, Siemens Corporate Technology, Siemens Healthineers, SubCom and Rutgers.


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About Rutgers, The State University of New Jersey

Rutgers, The State University of New Jersey, is a leading national research university and the state of New Jersey’s preeminent, comprehensive public institution of higher education. Established in 1766, the university is the eighth oldest higher education institution in the United States. More than 70,000 students and 23,400 full- and part-time faculty and staff learn, work, and serve the public at Rutgers locations across New Jersey and around the world.


As the premier public research university in the state, Rutgers is dedicated to teaching that meets the highest standards of excellence, to conducting cutting-edge research that breaks new ground and aids the state’s economy, businesses, and industries, and to providing services, solutions, and clinical care that help individuals and the local, national, and global communities where they live.


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